CAS 165450-17-9 Neotame
Synonyms: Neutame.;NEOTAME (200 MG);NEOTAME;N-(N-(3,3-Dimethylbutyl)-L-alpha-aspartyl)-L-phenylalanine 1-methyl ester;L-PHENYLALANINE, N-[N-(3,3-DIMETHYLBUTYL)-L-.ALPHA.-ASPARTYL]-, 1-METHYL ESTER;N-[N-(3,3-dimethylbutyl)-L--aspartyl]-L-phenylalanine 1-methyl ester;(S)-3-((3,3-DiMethylbutyl)aMino)-4-(((S)-1-Methoxy-1-oxo-3-phenylpropan-2-yl)aMino)-4-oxobutanoic acid;L-Phenylalanine,N-(3,3-diMethylbutyl)-L-a-aspartyl-,2-Methyl ester
CAS: 165450-17-9
MF: C20H30N2O5
MW: 378.46
EINECS: 605-408-8
Product Categories: Amines;Aromatics;Chiral Reagents;Intermediates & Fine
Neotame Chemical Properties:
Melting point: 83-85°C
alpha: D -54.84° (c = 1 in methanol); D20 -39.8° (c = 0.5 in water)
Boiling point: 565.3±50.0 °C(Predicted)
Density: 1.133±0.06 g/cm3(Predicted)
Storage temp.: -20°C Freezer
pka: pKa1 3.01; pKa2 8.02(at 25℃)
Form: neat
HS Code: 29242990
Intensity sweetener: Sweetener (intense Sweetener). Its sweetness is very high, usually it is 50 times higher than that of sucrose. According to different sources, there is a natural extract, natural product chemistry modified semisynthetic products and pure chemical synthesis products. A large supply of natural extracts is the main Stevia extract and long winded Sweet and natural product chemistry modified products such as aspartame, neotame and sucralose, pure synthetic chemical products such as saccharin, cyclamate and acesulfame.
Sweetener can be used for low calorie baked food sweetener, but must have a good thermal stability. Aspartame has been approved for use in food, but due to its poor thermal stability and is not suitable for baking food. American newt company newest development of neotame is aspartame derivative, its thermal stability and sweetness have greatly improved and sweet pure than aspartame, sweet good distribution is used for baking food, which has great potential for development of the sweetener.
It retains many excellent characteristics such as aspartame, pure sweet taste and good flavor enhancing properties distribution, no energy, no caries, stable in acidic medium. Moreover, it is still a lot better than aspartame in dry conditions, it has a longer shelf life; in neutral medium or instantaneous high temperature sterilization conditions, its stability greatly exceed aspartame, which can be used as a sweetener in baking. Neotame can also be used together with reducing sugar and aldehyde flavor without adverse reaction, its safety is better than aspartame and has been greatly improved. Due to its high sweetness, etc. Sweeter is lower than the cost of aspartame. Therefore, neotame has huge market potential. In December of 1998, neotame as food sweeteners status of application have been proposed in the United States, and some other countries for the certification work is in July 9, 2002 . The U. S. Food and Drug Administration (FDA) confirmed the neotame safety and functional type, currently is in March 10, worldwide more regulatory agency and national review in 2003, China's Ministry of Health approval for neotame as a sweetener used in all kinds of food.
Solubility: The solubility of neotame in water, is 12.6g/L at 25℃, aspartame is 10g/L. Achieve multiple solubility with 10% of sucrose solution equal sweetness, namely MRS10% numerical, is about 740. That is, neotame solubility ratio to reach 10% sucrose solution equal sweetness of solubility about 740 times. In contrast, the multiples of the aspartame is only about 19. It is worth that neotame is as salt (such as phosphate) or complex (such as beta-the link dextrin compound), its dissolution rate in water will increase significantly. Neotame in anhydrous ethanol solubility is very high, at 25℃ about 950g/L, over aspartame (25℃for 3.7g/l) 250 times.
Sweetness characteristics: It is the world's most sweet sweetener by far, is also the world's most safe sweetener tastes closest to sucrose.
Neotame pure sweet, is very close to aspartame, no other strong sweet agent, often with the bitterness and metallic taste. Under a variety of conditions, its flavor distribution are no significant difference from aspartame , while the neotame sweet stimulate the formation and sucrose is similar, but compared with aspartame, can feel the sweetness of the initial lag slightly, and the sweet taste of duration, slightly long. Similar with aspartame, in complex food system, it is according to need to be other ingredients, such as polyol, sucrose or containing oxygen acid to change these temporary effect.
Neotame in the human body can be quickly metabolism. The main metabolic pathway is through the body to produce the enzyme in the hydrolysis of methyl ester, the last generation of the defatted neotame and methanol. Neotame in human generated by decomposition of methanol is far not enough to pose a health hazard to the human body. Compared with ordinary food such as fruit, vegetables and vegetable juice, decomposed from neotame methanol volume is minimal. For example, tomato juice in methanol content exceeded containing neotame beverages 200 times. Neotame can with urine and feces completely eliminated from the body, not in the human body accumulation.
It can also enhance the flavor of certain foods and beverages, especially acid type fruit flavor (such as orange, lemon and grapes) and cherry flavor. And aspartame is different, neotame and acesulfame, saccharin has no synergistic effect between sweetness, providing more convenience for the new product development of food and beverage manufacturers, because neotame can be used alone, or with other nutritional or non nutritive sweeteners mixed use. Its appearance provides a more flexible solution for sweet food manufacturers. Adding can inhibit the aging of starch in starch food, prolong the shelf life of food products; in the egg, adding inhibited protein denaturation , keep good taste in fish protein rich food such as food.
Chemical Properties: Neotame occurs as an odorless, white to off-white powder. It has an intense sweet taste 7000–13 000 times sweeter than sucrose depending on the matrix.
Chemical Properties: Neotame is odorless and has an intense, sweet taste. It is 7,000 to 13,000 times sweeter than sucrose, depending on the food matrix. Normal metabolic processes convert neotame to de-esterified neotame and methanol. Based on its metabolism and extremely low use levels, neotame provides no calories. The stability of neotame is affected by moisture, pH and temperature
Uses: A labelled alkylated dipeptide reported to be 6000 to 10000 times sweeter than sucrose; structurally related to Aspartame. A non-nutritive sweetener.
Uses: Neotame is a high intensity sweetener and flavor enhancer for use in foods, except in meat and poultry. it is 7,000–13,000 times sweeter than sugar and has a clean, sweet taste. it is a derivative of the dipep- tide composed of amino acids, aspartic acid, and phenylalanine. it can be blended with nutritive sweeteners such as sucrose and high fructose corn syrup as well as with high intensity sweeteners such as aspartame and sucralose. uses include beverages, baked goods, desserts, cereals. it functions as a flavor enhancer in certain applica- tions and flavor systems, such as mint-flavored chewing gum.
Definition: A dipeptide composed of N-(3,3-dimethylbutyl)-L-aspartic acid and methyl L-phenylalanate units joined by a peptide linkage.
Pharmaceutical Applications: Neotame is a water-soluble, nonnutritive, intense sweetening agent used in beverages and foods. It is structurally related to aspartame and is about 7000–13 000 times sweeter than sucrose, and about 30–60 times sweeter than aspartame, making it the sweetest artificial sweetener available. Neotame is said to have a ‘clean’ sweet taste in contrast to the bitter, metallic aftertaste associated with saccharin. Although neotame has approximately the same caloric value as sucrose (1.2 kJ/g) the small quantities used to achieve a desired level of sweetness in a formulation mean that it is essentially nonnutritive.
Neotame may be used in sub-sweetening quantities as a flavor enhancer, e.g. with mint or strawberry flavor.
Storage: Neotame is stable in bakery products and pasteurized dairy products.
The bulk material should be stored in a well-closed container, in a cool, dry place; it is stable for up to 5 years at room temperature.
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