Product Name: Vitamin D3

Synonyms: Vitamin D3 solution;Vitamin D3-d3 Cholecalciferol (6,19,19-d3);Cholecalciferol d6;Vitamin D3-d6;10-Secocholesta-5,7,10(19)-trien-;(5Z,7E,3S)-9,10-Secocholesta-5,7,10(19)-trien-3-ol;3Z-[2E-[(1R,3aS,7aR)-1S-[1R,5-dimethylhexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-cyclohexanol;(+)-VITAMIN D/3, CRYSTALLINE, 99+%

CAS: 67-97-0
MF: C27H44O
MW: 384.64
EINECS: 200-673-2

Product Categories: DROMOS;Other APIs;Vitamin series;Inhibitors;Miscellaneous Compounds;Nutritional Supplements;Vitamin Ingredients;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Vitamins and derivatives;Vitamins - Deuterated;Miscellaneous Natural Products;Vitamin D3 analogs

Vitamin D3 Chemical Properties: 

Melting point: 83-86 °C(lit.)
alpha: 105 º (c=0.8, EtOH 25 ºC)
Boiling point: 451.27°C (rough estimate)
Density: 0.9717 (rough estimate)
vapor pressure: 2.0 x l0-6 Pa (20 °C, est.)
Refractive index: 1.5100 (estimate)
Fp: 14 °C
Storage temp.: 2-8°C
Solubility: Practically insoluble in water, freely soluble in ethanol (96 per cent), soluble in trimethylpentane and in fatty oils. It is sensitive to air, heat and light. Solutions in solvents without an antioxidant are unstable and are to be used immediately. A reversible isomerisation to pre-cholecalciferol takes place in solution, depending on temperature and time. The activity is due to both compounds.
Form: powder
pka: 14.74±0.20(Predicted)
Water Solubility: <0.1 g/L (20 ºC)
HS Code: 29130000
HS Code: 29362990

Chemical property: White columnar crystals or crystalline powder, odorless and tasteless

Uses:  Vitamin D3 can maintain normal metabolism of calcium and phosphorus, promote the body's absorption of calcium and phosphorus. When it is lacked, children are easy to get rickets. Regulations in China provides it can be used to strengthening margarine. The dosage is 125~156μg/kg. The dosage in fortified dairy products is 63~125μg/kg. The dosage in strengthening infant food is 50~100μg/kg. And the dosage in strengthening milk and milk drink is 10~40μg/kg. The largest dosage in the strengthening solid drinks and ice cream is 10~20μg/kg.

Chemical Properties: White or colorless crystalline solid. Odorless;

Uses: Vitamin D3 analogue.

Uses: carnitine replenisher in peripheral arterial disease

Uses: The vitamin that mediates intestinal calcium absorbtion, bone calcium metabolism and probably, muscle activity. Occurs in and is isolated from fish liver oils. Vitamin D acts through a receptor that i s a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects o n breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.

Uses: selective phosphodiesterase-4 inhibitor (PDE-4 inhibitor) under investigation for treating respiratory diseases involving chronic inflammation such as asthma or COPD (smoker’s lung)

Uses: Cholecalciferol and ergocalciferol are used for the control of rats and mice.

Agricultural Uses: Rodenticide: Used in bait for vermin control. Vitamin D is a steroid hormone that has an important role in regulating body levels of calcium and phosphorus, and in mineralization of bone. Not approved for use in EU countries. Registered for use in the U.S. and other countries.

Clinical Use: The principal disorder associated with inadequate vitamin D intake is rickets. The low blood calcium and phosphate levels that occur during vitamin D deficiency stimulate parathyroid hormone secretion to restore calcium levels. In children, this deficiency leads to the formation of soft bones that become deformed easily; in adults, osteomalacia results from the removal of calcium from the bone.Vitamin D deficiency may occur in patients with metabolic disorders, such as hypoparathyroidism and renal osteodystrophy. The requirement for vitamin D is slightly higher in members of darker-pigmented races, since melanin interferes with the irradiation that produces vitamin D3 in the skin. People with limited exposure to the sun may need to supplement vitamin D intake.
 

Shandong Green Chemical CO.,LTD is the premium producer and supplier of chemical raw materials. Our main products are food and feed additives,  agrochemicals,daily chemicals, pharmaceutical intermediates, organic intermediates, surfactants, dyes, plant extracts, cosmetics raw materials, chemical auxiliaries and other chemical raw materials. We are furnished with sophisticated production experience and strict quality control system,and our entire production process is conducted in more strict compliance with ISO 9001:2000 quality management system from sourcing raw materials, processing, inspecting and after-sale services and others.

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